46 research outputs found

    Scale-free networks are not robust under neutral evolution

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    Recently it has been shown that a large variety of different networks have power-law (scale-free) distributions of connectivities. We investigate the robustness of such a distribution in discrete threshold networks under neutral evolution. The guiding principle for this is robustness in the resulting phenotype. The numerical results show that a power-law distribution is not stable under such an evolution, and the network approaches a homogeneous form where the overall distribution of connectivities is given by a Poisson distribution.Comment: Submitted for publicatio

    Quasiperiodic Envelope Solitons

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    We analyse nonlinear wave propagation and cascaded self-focusing due to second-harmonic generation in Fibbonacci optical superlattices and introduce a novel concept of nonlinear physics, the quasiperiodic soliton, which describes spatially localized self-trapping of a quasiperiodic wave. We point out a link between the quasiperiodic soliton and partially incoherent spatial solitary waves recently generated experimentally.Comment: Submitted to PRL. 4 pages with 5 figure

    Quasiperiodic Hubbard chains

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    Low energy properties of half-filled Fibonacci Hubbard models are studied by weak coupling renormalization group and density matrix renormalization group method. In the case of diagonal modulation, weak Coulomb repulsion is irrelevant and the system behaves as a free Fibonacci chain, while for strong Coulomb repulsion, the charge sector is a Mott insulator and the spin sector behaves as a uniform Heisenberg antiferromagnetic chain. The off-diagonal modulation always drives the charge sector to a Mott insulator and the spin sector to a Fibonacci antiferromagnetic Heisenberg chain.Comment: 4 pages, 4 figures; Final version to appear in Phys. Rev. Let

    Quantum Return Probability for Substitution Potentials

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    We propose an effective exponent ruling the algebraic decay of the average quantum return probability for discrete Schrodinger operators. We compute it for some non-periodic substitution potentials with different degrees of randomness, and do not find a complete qualitative agreement with the spectral type of the substitution sequences themselves, i.e., more random the sequence smaller such exponent.Comment: Latex, 13 pages, 6 figures; to be published in Journal of Physics

    Remarks on the Spectral Properties of Tight Binding and Kronig-Penney Models with Substitution Sequences

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    We comment on some recent investigations on the electronic properties of models associated to the Thue-Morse chain and point out that their conclusions are in contradiction with rigorously proven theorems and indicate some of the sources of these misinterpretations. We briefly review and explain the current status of mathematical results in this field and discuss some conjectures and open problems.Comment: 15,CPT-94/P.3003,tex,

    Transmission and Spectral Aspects of Tight Binding Hamiltonians for the Counting Quantum Turing Machine

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    It was recently shown that a generalization of quantum Turing machines (QTMs), in which potentials are associated with elementary steps or transitions of the computation, generates potential distributions along computation paths of states in some basis B. The distributions are computable and are thus periodic or have deterministic disorder. These generalized machines (GQTMs) can be used to investigate the effect of potentials in causing reflections and reducing the completion probability of computations. This work is extended here by determination of the spectral and transmission properties of an example GQTM which enumerates the integers as binary strings. A potential is associated with just one type of step. For many computation paths the potential distributions are initial segments of a quasiperiodic distribution that corresponds to a substitution sequence. The energy band spectra and Landauer Resistance (LR) are calculated for energies below the barrier height by use of transfer matrices. The LR fluctuates rapidly with momentum with minima close to or at band-gap edges. For several values of the parameters, there is good transmission over some momentum regions.Comment: 22 pages Latex, 13 postscript figures, Submitted to Phys. Rev.

    A Quantitative Study of the Mechanisms behind Thymic Atrophy in Gαi2-Deficient Mice during Colitis Development

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    Mice deficient for the G protein subunit Gαi2 spontaneously develop colitis, a chronic inflammatory disease associated with dysregulated T cell responses. We and others have previously demonstrated a thymic involution in these mice and an aberrant thymocyte dynamics. The Gαi2−/− mice have a dramatically reduced fraction of double positive thymocytes and an increased fraction of single positive (SP) thymocytes. In this study, we quantify a number of critical parameters in order to narrow down the underlying mechanisms that cause the dynamical changes of the thymocyte development in the Gαi2−/− mice. Our data suggest that the increased fraction of SP thymocytes results only from a decreased number of DP thymocytes, since the number of SP thymocytes in the Gαi2−/− mice is comparable to the control littermates. By measuring the frequency of T cell receptor excision circles (TRECs) in the thymocytes, we demonstrate that the number of cell divisions the Gαi2−/− SP thymocytes undergo is comparable to SP thymocytes from control littermates. In addition, our data show that the mature SP CD4+ and CD8+ thymocytes divide to the same extent before they egress from the thymus. By estimating the number of peripheral TREC+ T lymphocytes and their death rate, we could calculate the daily egression of thymocytes. Gαi2−/− mice with no/mild and moderate colitis were found to have a slower export rate in comparison to the control littermates. The quantitative measurements in this study suggest a number of dynamical changes in the thymocyte development during the progression of colitis

    Effect of ochratoxin A on the intestinal mucosa and mucosa-associated lymphoid tissues in broiler chickens

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    The immunotoxic effect of ochratoxin A (OTA) on the intestinal mucosa-associated lymphoid tissue and its cytotoxic action on the intestinal epithelium were studied in broiler chickens experimentally treated with the toxin. From the 7th day of life, 80 male broiler chickens (Ross 308) were randomly divided into four groups of 20 birds each. The three experimental groups (E1-3) were treated with OTA for 28 days (E1: 50 μg/kg body weight [bw]/day; E2: 20 μg/kg bw/day; E3: 1 μg/kg bw/day) and the fourth group served as control. Histological examination of the intestinal mucosa and immunohistochemical staining for identification of CD4+, CD8+, TCR1 and TCR2 lymphocytes in the duodenum, jejunum and ileocaecal junction were performed, and CD4+/CD8+ and TCR1/TCR2 ratios were calculated. OTA toxicity resulted in decreased body weight gain, poorer feed conversion ratio, lower leukocyte and lymphocyte count, and altered intestinal mucosa architecture. After 14 days of exposure to OTA, immunohistochemistry showed a significant reduction of the lymphocyte population in the intestinal epithelium and the lamina propria. After 28 days of exposure, an increase in the CD4+ and CD8+ values in both the duodenum and jejunum of chickens in Groups E1 and E2 was observed, but the TCR1 and TCR2 lymphocyte counts showed a significant reduction. No significant changes were observed in Group E3. The results indicate that OTA induced a decrease in leukocyte and lymphocyte counts and was cytotoxic to the intestinal epithelium and the mucosa-associated lymphoid tissue, altering the intestinal barrier and increasing susceptibility to various associated diseases
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